In this line of research, we propose quantitative assessment of cancer angiogenesis by combining dynamic contrast-enhanced imaging with pharmacokinetic modeling of the contrast agent kinetics. This enables the extraction of interpretable parameters that can be used for cancer diagnostics. 
In perioperative care, the timely prediction of patient deterioration has as a pivotal role in ensuring optimal patient outcomes and the efficient allocation of resources within hospital settings. The ability to foresee changes in a patient’s condition before they escalate into critical states is paramount for healthcare providers seeking to deliver high-quality and patient-centered care. In this line of research, we develop novel strategies for timely prediction of patients at risk. 
Prostate cancer is the second most common form of cancer and one of the most lethal in western men. Timely and accurate diagnosis is crucial. Multiparametric MRI is currently the recommended imaging modality for prostate cancer. However, it is not sufficiently accurate to replace systematic biopsies. In this line of research, we extract quantitative parameters from multiparametric MRI and combine them by machine learning for improving prostate cancer diagnostics. Additionally, we investigate the link between relevant MRI features and genomic features of aggressive prostate cancer.
Ultrasound contrast agents (UCAs) have significantly expanded diagnostic possibilities through the concurrent application of indicator dilution principles and dynamic contrast-enhanced ultrasound (DCE-US) imaging. In this line of research, we develop quantitative analysis methods to extract multiple quantitative maps from DCE-US, reflecting complementary variables of underlying physiological processes. Using probabilistic frameworks based on emerging machine-learning methods, we aim to enhance the diagnostic accuracy of DCE-US imaging through the optimal combination of extracted complementary information. 
Mechanical ventilation is a critical medical intervention employed to support patients with compromised respiratory function. While mechanical ventilation is essential in various clinical settings, including intensive care units and emergency situations, it is not without potential risks and complications. This line of focuses modeling and analysis of mechanical ventilation for better assessment of patient’s efforts with the aim of reducing potential risks.
Novel contrast agents composed of nanobubbles (~300 nm) are being developed to overcome the limitations of standard clinically-available ultrasound contrast agent. Because of their smaller size, nanobubbles can cross the vascular endothelium and reach targets beyond the vessel wall, opening up new avenues for assessment of vascular permeability and the expression of cancer-specific targets. In this line of research, we developed pharmacokinetic model describing the transport of the nanobubbles in the vasculature and their distribution in tissue, with the aim of extracting quantitative cancer biomarkers. 
Hemodynamic monitoring in hospitals involves the continuous observation and assessment of blood circulation and cardiovascular function in patients. This process is crucial for understanding and managing conditions that affect the heart and blood vessels. In this line of research, we develop novel theoretical and experimental methods for assessing hemodynamics function, using standard clinical equipment. 